This is a picture of a muscle cell infected with Danons disease.
The vacuole is a very dangerous organelle. The malfunction of the vacuole can cause disease such as Danon disease. Danons disease is cause by mutations in the LAMP 2 gene which usually helps with the fusion of autophagic vacuoles and lysosomes. When there are mutations with this gene then the lysosomes and the autophagic vacuole fuse very slowly. By slowly fusion this allows the number of autophagic vacuoles to increase substantially. If there is a large amount of autophagic vacuoles then this leads to the breakdown of muscles cells which is shown in Danons disease. Males with Danons disease usually die at the young age of 19; while females usually die at the age of 31.
The Vacuole is not fit enough to be our chief. If we have too much of the vacuole it can lead to serious diseases such as Danons disease. Too many vacuoles cause damage to the cell. This is why we should not vote for the vacuole to be our commander and chief.